Rapid progression to Richter’s syndrome in patient with chronic lymphocytic leukemia and near-triploid karyotype

Introduction. The presence of aneuploidy in patients diagnosed with chronic lymphocytic leukemia (CLL), except trisomy 12, is considered quite uncommon. Hyperdiploidy or near-tetraploidy (occurring 1?3% all CLL patients) usually confer a poor prognosis. Case report. We report patient progressive phase near?triploid karyotype. prognosis the disease was more precisely determined by applying cytogenetic analysis karyotype and complemented molecular methods pathohistological examination. complex accompanied TP53, C-MYC, IGH gene disruptions, most probable cause rapid evolution into Richter?s syndrome. Conclusion. use comprehensive contemporary diagnostic techniques highly recommended who are CLL, primarily for adequate choice management strategy. presented case confirms that indicates prognosis, which accordance previous publications reporting on cases aneuploidy.